The vibration and noise reduction of the heating, ventilation and air conditioning (HVAC) system is one of the most important issues for the scientific research vessels, because the noise of the HVAC system will not only affect the sea trials that are carried out by the scientists, but also have a great influence on the work and life of the crew. It introduces the vibration and noise reduction characteristics of the HVAC system for the “Dongfanghong 3” scientific research ship. It also presents the methods and measures for the vibration and noise reduction design of the HVAC system. It can provide reference for the research of the vibration and noise reduction technology for the HVAC system of scientific research vessels and similar ships.